AML
Cytogenetics: Karyotyping (Oncology)
| FISH | Molecular genetics | NGS |
|---|---|---|
| t(9;22) (q34;q11.2) BCR – ABL1 dual fusion | BCR – ABL1 P210 Quantitative PCR | Oncomine Myeloid 85 genes DNA + RNA |
| BCR – ABL1 Genotyping (p190, p210, p230) | ||
| t (15;17) (q24; q21) PML – RARA dual fusion | PML – RARA Quantitative PCR | |
| t (8;21) (q21; q22) RUNX1 – RUNX1T1 (AML – ETO) dual fusion | RUNX1 – RUNX1T1 AML – ETO t (8;21) | |
| CBFB 16q22 Break Apart | FLT3 ITD & TKD | |
| JAK2 9p24 Break Apart | NPM1 (A, B & D) | |
| NTRUK3 15q25 Break Apart | FLT3 Sequencing | |
| Chromosome 8 trisomy | TP53 Sequencing | |
| Chromosome 5q- Deletion | JAK2 V617F | |
| Chromosome 7 Deletion | JAK2 Sequencing | |
| t (3;21) (q26; q22) MECOM – RUNX1 dual fusion | ||
| P53 17p13 CNV | IDH1 / IDH2 |